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3.2 The Up-Stream Regulatory Mechanisms of Ferroptosis 3.2.1 System X c The cystine-glutamate antiporter System X c is a disulfide-linked heterodimer composed of a light chain XCT and a heavy chain 4F2, namely, substrate-specific subunit SLC7A11 and regulatory subunit SLC3A2 (Song et al., 2018

Research shows this mechanism gives insights into fat metabolism, muscle health and NAD+ biology

The following sections will explore the role of ferroptosis and its interaction with these established pathways

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Next, we isolated activated ILC2s from the lungs of IL-33 challenged mice, subsequently treating them with morpholinos to block the translation of NRF2 whilst treating them with melatonin ( Figures 7A, G )