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The decision to ban compounded medications comes after the FDA identified a growing number of unapproved compounded drugs in the market, including versions of FDA-approved medications like semaglutide, which are being produced without proper regulatory oversight

10.3389/fneur.2020.00840 Front

Logroscino G, Tortelli R, Rizzo G, Marin B, Preux PM, Malaspina A

Although the available evidence is limited in design, sample size, and outcome definitions, it supports this perspective

Damage to the tight endothelial junctions results in increased BBB permeability, leading to the entry of immune cells and inflammatory cytokines into the parenchyma, as well as impaired clearance of metabolic waste and neurotoxic compounds (Zlokovic, 2004