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Emotional state Stress can cause your body to divert blood from your stomach and small intestines to your muscles, and slow down the rate of absorption of alcohol into your bloodstream

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Loss-of-function mutations in the BCKDK gene are associated with a phenotype that is characterized by persistently reduced levels of BCAA in body fluids, developmental delay, microcephaly, and neurobehavioral abnormalities

Adherence could also be a greater issue with combination therapy versus a single/linear therapy approach because the more drugs a patient needs to take each day the greater the potential for poor treatment adherence [52]