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Hormonal changes are typically secondary to weight loss, insulin sensitivity shifts, and energy balance changes

Rather than identifying definitive diagnostic biomarkers, this study highlights a small number of metabolitesmost notably leucine, betaine, and coumarinthat may contribute to metabolic stratification of ASD in future work

Both experimental and clinical evidence support the therapeutic potential of these antioxidants in the prevention and treatment of oxidative stress-related diseases, especially when used in combination with conventional therapies or in targeted formulations

From a translational perspective, rodent obesity models often tend to amplify efficacy signals compared to humans, Yi says