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use ibuprofen without consulting a specialist in the following cases: It is contraindicated in patients who have demonstrated hypersensitivity to the drug or any of its components, to aspirin, to salicylates or to other non-steroidal anti-inflammatory drugs

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Importantly, overexpression of the YAP mutant (YAP-5SA) attenuates the inhibition of metformin on the stem and epithelial-mesenchymal transformation of glioma cells