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Description

Abstract In healthy humans, the incretin glucagon-like peptide 1 (GLP-1) is secreted after eating and lowers glucose concentrations by augmenting insulin secretion and suppressing glucagon release

Furthermore, aging and HFD-induced obesity increase CD38 expression in macrophages and the vascular endothelium

It should be clear

By around one year, some people may be close to 25% weight loss, with Phase 3 data showing up to 28.7% by week 68

Neuroimaging studies indicate decreased activity in reward regions when exposed to food signals, implying an alteration in hedonic eating behaviour (Devoto et al