Clinical trials suggested that 2.4 mg of semaglutide once weekly was associated with a sustained, clinically relevant reduction in body weight when combined with lifestyle interventions like a healthy diet and exercise
The setup, per Lilly's investor disclosures and ClinicalTrials.gov: Duration: 80 weeks of treatment (the longest of any TRIUMPH trial) Population: Adults with obesity (BMI 30) or overweight (BMI 27) plus at least one weight-related comorbidity, without type 2 diabetes Doses: 4 mg, 8 mg, and 12 mg retatrutide vs matched placebo, all once-weekly subcutaneous Primary endpoints: Mean percent change in body weight
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