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Effects of l-theanine on attention and reaction time response

Under low testosterone levels, the expression of genes related to glucose transport is downregulated, including insulin receptor substrate 1 (IRS-1), insulin receptor subunit (IR-), glucose transporter 4 (GLUT4), AKT serine/threonine kinase-2 (AKT2), and solute carrier family 2 member 4 (SLC2A4) [150, 151]

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Consequently, CHAC1 serves as a central mediator connecting ISR (ATF4) to the antioxidant response (NRF2) and metabolic adaptation (SLC7A11), thereby enabling cells to dynamically fine-tune redox homeostasis and maintain metabolic flexibility during stress (Kre et al., 2023)

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