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This increases the oxidative burden in the body because of the excessive amounts of oxidized glutathione waiting to be recharged by antioxidants

[20] Symptoms like irritability, anxiety, poor sleep, gross motor problems or problems with coordination, tics, seizures, vision problems, developmental delay and/or slowing of typical development, and depression have been reported in those with FRAs and while testing folate levels in the CSF is too invasive, a test for folate receptor antibodies is available

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doi: 10.3389/fendo.2014.00129 Hansen BS et al