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Current evidence doesnt point to a specific causal relationship that directly links GLP-1 drugs and microbial overgrowths, but the underlying mechanics and possible resulting effects certainly warrant a degree of caution

The search strategy combined the Medical Subject Heading (MeSH) terms exenatide OR liraglutide OR semaglutide OR dulaglutide OR albiglutide OR lixizenatide AND diabetes mellitus, type 2 AND a filter to identify RCTs 14

Foundayo 12.4% vs oral Wegovy 16.6% (efficacy estimand) Foundayo 11.2% vs oral Wegovy 13.6% (Both all-comers:) So that means 11.2% for Foundayo and 13.6% for Wegovy, which is a significant win for Wegovy

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Personalizing Your Injection Site Strategy With Genetic Insights Individual response to semaglutide depends partly on genetic variations affecting GLP-1 receptor function, insulin sensitivity, and metabolic rate