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In some cases, external hemorrhoids may thrombose (form a blood clot), causing severe pain and a firm lump near the anus

Injecting every 5 days would cause faster drug accumulation than what was tested, potentially increasing side effects without proven benefit

Diabetes Metab Res Rev (2016) 32(8):77690

Patients who are overweight and have certain comorbidities specifically, heart disease risk factors may also find that their insurance will cover the prescription

32 The primary outcome for the trial was the first occurrence of a major adverse cardiovascular event (death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke)