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This is particularly important because, like many herbal supplements, milk thistle can interact with certain prescription drugs, including those metabolized by the livers cytochrome P450 enzyme system, such as some cholesterol-lowering statins, blood thinners, and anti-diabetic medications

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A 2023 analysis comparing GLP-1 drugs found that triple-receptor agonists like retatrutide produced greater reductions in caloric intake in the first two weeks compared to single or dual receptor drugs