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Elevated levels of serum Interleukin-8 (IL-8) in T1DM individuals with poor glucose control may contribute to an inflammatory response that has shown to lower IGF-1 levels in chronic inflammatory diseases [74]

Peptide WH was relatively stable in simulated gastrointestinal digestion and was able to maintain the IC 50 value for -glucosidase inhibition (17.03 0.05 mol/L), whereas WS significantly increased the IC 50 value after simulated digestion (24.71 0.02 mol/L to 44.63 0.03 mol/L) (68)

While not listed as an official side effect in FDA labeling, this sensation is a common physiological response to the significant weight loss these medications produce

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