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The accumulation of cysteine, which originates from GSH, substantially increased excitotoxic damage and disrupted the balance of GSH/GSSG tissue damage caused by stroke in a rat model (Qu et al., 2006)

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme present in every living cell, essential for mitochondrial energy production, DNA repair, and sirtuin activation

Glutathione reductase uses energy and NADPH, the thing that you can't make, to recycle glutathione

Interestingly, previous research has shown upregulation of GPX4 at the transcriptome level during these stages [15]