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However, when APAP is ingested in excessive amounts, the capacity of GSH to neutralize NAPQI becomes overwhelmed, leading to depletion of hepatic GSH stores and accumulation of NAPQI, resulting in oxidative stress, mitochondrial dysfunction, and hepatocellular injury, ultimately culminating in acute liver injury and potential liver failure
Together, secondary analyses of the GOLDEN 3 and 4 studies show that nebulized GLY was generally well tolerated in subgroups of patients, regardless of their age, gender, disease severity, background LABA or baseline rescue medication use, or comorbidities at baseline
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