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Using biotin-probe profiling, gene knockout/knock-in models, UPLC-MS metabolomics and computational simulations, the researchers demonstrated that: CD36 binds multiple PROTAC molecules (including SIM1-Me, MZ1 and ARV-110) as well as large-molecule drugs such as rapamycin, navitoclax, birinapant, tubacin and doxorubicin, thereby promoting their cellular uptake and pharmacological activity

Additionally, it has beneficial effects on patients glycemic and blood pressure control, serum high-sensitivity C-reactive protein (hs-CRP) levels, total cholesterol/HDL cholesterol ratio, total cholesterol, and mental health parameters [209]

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Arch Dermatol 141, 13811387 (2005)