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The combination leads to endothelial dysfunction, cholesterol deposition, inflammation, and finally, calcification.[ref] Oxidized phospholipids are primarily polyunsaturated fatty acids that are oxidized due to ROS, infections, or apoptosis

These medications are licensed in the UK for specific indications and prescribed according to NICE guidance, primarily for managing type 2 diabetes and, in some cases, obesity

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The expressed proteins of GSTP-silenced and control siRNA-treated cells on Day 4 after siRNA transfection were quantitatively compared