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Supplementary material The Supplementary Material for this article can be found online at: References 1 AckermannJ.MerkelyG.MestrinerA

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In acute respiratory distress syndrome, the shedding of the epithelial glycocalyx contributes to the development and progression of lung injury, including excessive alveolar permeability, disruption of surfactant function, greater bacterial virulence, and impaired epithelial cell repair (44)

This mechanism means AOD-9604 does not require appetite suppression to be effective, making it suitable for individuals who do not struggle with appetite control or who cannot tolerate the gastrointestinal side effects common with GLP-1 agonists