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The SURMOUNT-4 trial assessed the weight maintenance with tirzepatide and had also two periods: a 36-week open-label lead-in period during which all participants took tirzepatide, followed by a 52-week double-blind treatment period during which participants were randomised to either continue on tirzepatide or switch to placebo

Remaining contenders faced a five-factor scorecard: Clinical safety and lab monitoring Price transparency: total yearly cost with no hidden pharmacy fees Patient satisfaction drawn from at least twenty public reviews Convenience, including travel time and telehealth flexibility Extra credentials or integrated services that add clear value Each factor carried a weight

Here are just two examples: Leptin resistance Leptin is a hormone that controls your appetite and regulates how much fat your body burns

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If you consistently experience problematic injection site reactions despite good technique, the route of administration may not be right for you