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In the SELECT trial that included over 17,000 patients with obesity and established CV disease, but without diabetes, weekly s.c

However, because insulin is released largely in response to rising glucose after carbohydrate intake, glucose patterns act as a useful surrogate for insulin exposure

It is part of the incretin family, which is released after eating to help regulate blood sugar and energy balance

But it cannot replace: consistent meal structure adequate protein intake fibre from whole foods micronutrient sufficiency stable blood sugar patterns reduced inflammatory food exposure Metabolism is built through daily behaviour

By activating GLP-1 receptors, retatrutide helps stimulate insulin secretion in a glucose-dependent manner, reduces appetite, and slows gastric emptying contributing to improved blood glucose control and reduced caloric intake