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Although bariatric surgery can lead to weight loss of at least 25% and long-term weight maintenance, it is not scalable at the population level, and many people are still afraid to have surgery because of the possibility of complications, [135, 136]

The MOTS-c analog CB4211 was well-tolerated in a Phase 1 trial with 85 participants and no serious adverse events

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Inefficient intracellular methylations may lead to the chronic damage of numerous proteins, which might in turn be involved in atherothrombogenesis