Contraindications across the group commonly include pregnancy or breastfeeding and being under 18, with additional considerations such as active or recent cancer (CJC + Ipamorelin, IGF-1 LR3), active malignancy (Sermorelin), uncontrolled blood sugar disorders (CJC + Ipamorelin), uncontrolled metabolic or endocrine disorders (IGF-1 LR3, MOTS-C), severe liver or kidney disease (MOTS-C), autoimmune disorders requiring careful metabolic regulation (MOTS-C), and use of insulin or oral hypoglycaemic medications due to hypoglycaemia risk (MOTS-C)
In general, the SCFAs-FFAR 2 signaling pathway is beneficial for improving cholesterol metabolism and reducing LDL-C levels
While one promises energy and power, the other claims to support fat-burning and endurance
pharmaceutical company Eli Lilly have also seen a steep rise in sales over the past few years
* Pain when extending the wrist against resistance