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Egg cells are highly energy-dependent, and mitochondrial function appears to become increasingly important as women age

Ono YJ, Tanabe A, Nakamura Y, Yamamoto H, Hayashi A, Tanaka T, Sasaki H, Hayashi M, Terai Y, Ohmichi M

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Clinical research Research published in the Journal of Pharmacology and Experimental Therapeutics (McCoy et al., 2013) evaluated metabolically stabilized angiotensin IV analogs, including Dihexa, as pro-cognitive and anti-dementia agents, demonstrating meaningful cognitive improvements in animal models

Biochemical assessments of peripheral blood from AD patients demonstrated significantly elevated levels of the mitochondrial fission factor Fis1, with postmortem brain specimens further revealing upregulated Drp1 expression in AD cases (Pakpian et al., 2020)