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Patten CJ, Thomas PE, Guy RL, Lee M, Gonzalex FJ, Guengerich FP, Yang CS: Cytochome P450 enzymes involved in acetaminophen activation by rat and human liver microsomes and their kinetics

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Crucially, FOXO4-DRI selectively induced apoptosis in senescent TM3 Leydig cells by causing nuclear exclusion of active Ser15-phospho-p53, leading to a significant increase in apoptosis rate and altering pro-apoptotic (BAX, cleaved-Caspase3 increase) and anti-apoptotic (BCL-2 decrease) protein levels