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Quick Answer: Tirzepatide and metformin can be safely combined for enhanced weight loss and glycemic control, with tirzepatide providing potent appetite suppression (15-22% weight reduction) and metformin offering insulin-sensitizing effects and modest additional weight loss (2-3%)

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Biomarker assessment can help contextualize whether your response reflects typical adaptation or a genetic predisposition requiring earlier intervention

Time to event was estimated and visualized using the Kaplan-Meier method and presented as disease-free survival

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