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10.1104/pp.15.00026 Plant Physiol

Mounting evidence indicates that patients with DKD commonly exhibit gut microbiota dysbiosis, altered bile acid pool composition, and aberrant expression of bile acid receptorsparticularly Farnesoid X Receptor (FXR) and Takeda G proteincoupled receptor 5

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10.3390/ijms24129982 7 AscenoK.SzaboC

The peptide downregulates or inhibits key lipogenic enzymes including fatty acid synthase and acetyl-CoA carboxylase, which are responsible for converting excess dietary carbohydrates and other substrates into fatty acids for storage