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BMC Genomics 19:789 Mu DS, Li CY, Zhang XC, Li XB, Shi L, Ren A, Zhao MW (2014) Functions of the nicotinamide adenine dinucleotide phosphate oxidase family in Ganoderma lucidum : an essential role in ganoderic acid biosynthesis regulation, hyphal branching, fruiting body development, and oxidative-stress resistance

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In severe cases, it can lead to conditions like osteoporosis