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While medications like semaglutide focus on a single pathway that helps control appetite and blood sugar, tirzepatide activates two complementary pathways at the same time

Clinical data shows no direct pharmacological conflict between these drug classes, but gastrointestinal side effects from semaglutide can indirectly influence bleeding risk

Non-genetic predictors of BMI loss To analyse the dependence of achieved BMI loss on non-genetic factors such as drug type, dosage and time on treatment, we fit the following model: where drugType is an indicator variable that equals 1 for individuals using semaglutide and 0 for tirzepatide, dose represents the dose in milligrams, days treat represents the total days on the relevant drug and : represents an interaction term between two or more variables