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These findings suggest a dual role for iron in M1 macrophages: while endogenous iron sequestration may facilitate ferroptosis, excess extracellular iron may conversely suppress inflammatory activation

Titrate semaglutide and tirzepatide more slowly (hold each dose level for four weeks instead of the standard two to four weeks) if GI side effects are severe

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Not surprisingly, since many AMPs attached to DNA web should be normally restricted in cytoplasmic granules, their release may have harmful effects such as degrading ECM or activating tissue-destructive mechanisms [93, 94]

If shedding begins within a few (2-4) months after starting GLP-1 therapy , it might be related