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Whats more, a recent retrospective, multicenter cohort study denied higher occurrence of nonarteritic anterior ischemic optic neuropathy (NAION) in GLP-1RAs users and suggested that its potential benefits for blood glucose control and cardiovascular health likely outweigh its risks (Table 1

10.3389/fphar.2023.1152042 [DOI] [PMC free article] [PubMed] 174.Zhang Y et al

Always contact your healthcare provider before stopping GLP-1 therapy if concerning symptoms develop, as abrupt discontinuation can trigger rapid weight regain and metabolic rebound

Thus, the modulation of the dopamine transporter by GLP-1r signaling likely plays an important role in the impact of GLP-1 agonism on psychostimulant induced behaviors in the lateral septum

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