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People can also have 'normal' levels of B12 in their blood, but be symptomatic - this is known as a functional B12 deficiency

Several later papers involved authors with commercial development interests

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In 1948, Rathbun first described the disease as hypophosphatasia in an infant, presented with severe bone loss, seizures, and low levels of alkaline phosphatase tissue and blood, who died of tonic epilepsy at 2 months of age [39]