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In patients with cardiovascular disease complicated by moderate cognitive impairment, the treatment group received intravenous L-carnitine followed by oral acetyl-L-carnitine in addition to basic treatment, and its cognitive indicators were better than those of the group receiving only basic treatment, with no adverse reactions

to the best of our knowledge, no other studies addressed the effects of l-ARG supplementation in patients with severe ED of any etiology, and, particularly, no studies specifically focused on severe ED of vasculogenic etiology, by excluding different forms of disease

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All clinical investigations were conducted according to Declaration of Helsinki principles

Finding the ulcer-related underlying cause of the bleeding is the first treatment step