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NAD+ levels in human skin decline with age, and this decline affects multiple repair mechanisms simultaneously: DNA repair capacity (through PARP enzyme activity), mitochondrial energy production in skin cells, autophagy of damaged proteins, including glycated collagen, and the sirtuin-mediated preservation of collagen integrity

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Methods Enzymol 1(541):310 Lawrence RA, Burk RF (1976) Glutathione peroxidase activity in selenium-deficient rat liver

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A native gene would enable knockout models, expression mapping and antibody validation