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While efficacy endpoints for weight loss in those trials were modest, the compound exhibited a favorable safety profile, supporting its later GRAS designation for food use

As of June 2026, neither compound is FDA-approved

Coding pernicious anemia based on clinical suspicion alone invites audit scrutiny

Further research is needed to better understand the interplay between the DA system, glutamatergic system, and other neurotransmitter systems to improve interventions for preventing and treating alcohol dependence