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2024;9:234 Rosenstock J, Sorli CH, Trautmann ME, Morales C, Wendisch U, Dailey G, et al

GLP-1 receptor agonists are commonly associated with gastrointestinal adverse events, which may lead to dehydration in some people [112]

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There are also other practical reasons to prescribe these drugs in people with type 2 diabetes, because all three classes are associated with relatively low risk of hypoglycemic events, while patients treated with GLP-1RA and SGLT-2 inhibitors may also benefit from weight loss [11]

Administering the lowest effective microdose and waiting extended periods between dose increases is the standard protocol for reducing gastrointestinal distress in animal models and human trials