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Rationale for GLP-1/Glucagon Combination Therapy for Weight Loss Although significant progress was made in understanding the potential use of the endogenous GLP-1/glucagon co-agonist OXM as a weight loss therapeutic in the early 2000s, evidence from various pre-clinical and human studies prior to this demonstrated the distinct mechanisms of weight loss afforded by these hormones

It notes no clinically relevant effect on gastric emptying rate at the 2.4 mg dose and no clinically relevant interactions with the oral medications tested

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Dopamine Regulation and Brain Chemistry Dopamine is a neurotransmitter, which means it helps send messages between brain cells