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Proceedings of the National Academy of Sciences of the United States of America, 94 (5), 1967

Increased Intestinal Permeability Precedes Clinical Onset of Type 1 Diabetes

Horvat et al

(download XLSX Gene IDs and primer sequences for the genes used for qPCR verification

Once activated, ERK1/2 is transferred to the nucleus, where it phosphorylates transcription factors such as c-Myc and c-Fos, leading to the expression of genes responsible for cellular regulations such as cell proliferation, differentiation, and migration