Novo Nordisk (Denmark) and Eli Lilly & Co
Validation of DM2 DMTs in AD prevention using blood transcriptomic data from patients with MCI To validate the impact of DM2 DMTs, including metformin, in preventing AD comorbidity in DM2, we analyzed publicly available blood transcriptomic data from patients with MCI, a well-established preclinical stage of AD
Within the gutbrain framework, enteroendocrine cells act as chemosensory sentinels that translate luminal cues into endocrine and paracrine signals detected by vagal afferents, providing a concrete route through which microbiota-derived signals could modulate neuroendocrine circuits relevant to therapeutic heterogeneity (16, 68)
Such responses may vary from mild discomfort to serious cases
As low birth weight has been identified as the leading cause of infant mortality in the United States (104), such associations should require considerable attention during family counseling
