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GLP-1 receptor agonists and renal outcomes Based on the US FDA industry guidance issued in 2008, all new glucose-lowering agents were required to perform a large-sized placebo-controlled cardiovascular outcome/safety trial, usually conducted in people with T2D with pre-existent or at high-risk of developing CVD

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These findings have stimulated clinical development attempts, particularly for NAD + modulators deemed suitable for human trials in terms of safety and upscaling, such as natural precursors