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By blocking NNMT, the compound is associated with preserved NAD+ levels and reduced fat storage, alongside improvements in cellular energy utilization and insulin sensitivity

Peptide transformations typically preserve more lean mass compared to diet-only approaches, though dedicated resistance training remains essential for optimizing body composition outcomes

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Notably, the hyperglycemic and high-AGE microenvironment within the DW vasculature and surrounding tissue actively reinforces and sustains the pro-inflammatory M1 macrophage phenotype through multiple interconnected mechanisms (Yu et al., 2025)

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