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Would be interested to hear from any hypotheses why the signal for PAD/Lower limb complications for SGLT2i, and the signal for eye complications for more potent GLP1s.

J Hepatol 65:579588 Tveden-Nyborg P, Birck MM, Ipsen DH, Thiessen T, Feldmann LB, Lindblad MM, Jensen HE, Lykkesfeldt J (2016) Diet-induced dyslipidemia leads to nonalcoholic fatty liver disease and oxidative stress in guinea pigs

They also modulate insulin secretion in a glucose-dependent manner, improving glycemic control without significantly increasing hypoglycemia risk in non-diabetic patients

The relevance of these findings to humans is not established, but semaglutide is contraindicated in people with a personal or family history of medullary thyroid carcinoma or MEN2

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