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In a briefing document released prior to the panel discussion, the FDAs internal reviewers said that Ocaliva had failed to demonstrate efficacy in one of its confirmatory trials

Serious Side Effects Contact your healthcare provider immediately if you experience: Persistent or severe abdominal pain, which could be acute pancreatitis or gallbladder disease

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Your protocol, your pace

How B12 Deficiency Affects Your Metabolism and Energy Now, while B12 doesn't directly cause weight gain, a deficiency can certainly have an indirect impact on your body's energy levels and, consequently, your activity and metabolism