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If TSH rises or falls outside the target range during tirzepatide therapy, thyroid medication doses may need adjustmentnot necessarily the tirzepatide dose

As a precaution, the FDA warns patients with a personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2) should avoid using Zepbound (Tirzepatide)

A study published in Frontiers in Endocrinology advised that, since both oral and injectable semaglutide are effective, the choice between them should be based on individual preferences, convenience and specific health needs, ensuring the treatment best aligns with the patients lifestyle