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Clinical trials published in the Journal of the American Medical Association (JAMA) also showed improvements in blood pressure and cholesterol levels in some patients (source)

These effects were achieved under reduced activation of noncanonical signaling pathways including receptor internalization and -arrestin recruitment, an initially surprising observation as these have previously been linked to increased GLP-1R responses when measured acutely 10,14,36

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Simon analyze commercial insurance claims for approximately 537,000 patients who initiated GLP-1 treatment between 2017 and 2022