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Ethics declarations Competing interests The authors declared no conflict of interest

Progress monitoring approaches Subjective assessment of pain, function, and activity tolerance provides the most accessible progress monitoring

Previous work has indicated that Src activates PDK1 via the phosphorylation of tyrosine residues [44] and has identified PI3K as a regulatory component lying upstream of PDK1 [45, 46]

(9) In LPS-stimulated hepatocytenonparenchymal cocultures, GHRP-2 apparently reduced TNF- mRNA and nitrite/nitrate release, which are important inflammatory markers

If PIH occurs, it typically resolves within weeks to months after treatment stops