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10.1021/acs.molpharmaceut.7b00365 108 MaiX.YinX.ChenP.ZhangM

Indian J Med Sci (2010) 64:37884

22 Hyperglycemia-driven ROS overproduction predominantly arises from two mechanisms: 66 Glucose Autoxidation (animal model, in vitro data): Direct generation of ROS via glucose metabolism intermediates by NOS, NADPH oxidases, xanthine oxidase, and hemeperoxidase enzymes, such as myeloperoxidase

Studies isolating the weight-loss effect from the GLP-1 effect find that roughly 4050% of blood pressure improvement occurs independent of pounds shed