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No GLP-1 receptor agonist currently has FDA approval for treating binge eating disorder

Glucagon-Like Peptide I and glucose-dependent insulinotropic polypeptide stimulate Ca2+-induced secretion in rat -Cells by a protein kinase A-mediated mechanism

retatrutide is an incretin-based triple agonist adding GIP, GLP-1, and glucagon activity

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| Medication | Monthly Cost (2026) | Mechanism | Avg Weight Loss | |-----------|-------------------|-----------|-----------------| | Retatrutide (compounded) | $200650 | Triple agonist (GLP-1/GIP/glucagon) | 24% | | Wegovy (semaglutide) | $1,300+ | GLP-1 only | 15% | | Zepbound (tirzepatide) | $1,059+ | Dual agonist (GLP-1/GIP) | 21% | | Mounjaro (tirzepatide) | $1,023+ | Dual agonist (GLP-1/GIP) | 21% | | Ozempic (semaglutide) | $935+ | GLP-1 only | 12-14% | *Note: Compounded retatrutide prices reflect direct pharmacy costs with valid prescription