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Higher Risks of Gastrointestinal Effects in Diabetic Patients In October 2023, The Journal of the American Medical Association(JAMA), examined adverse events in patients with diabetes associated with GLP-1 RA in a research letter called Risk of Gastrointestinal Adverse Events Associated With Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss where it concluded that studies have found increased risks of gastrointestinal adverse events, such as biliary disease, pancreatitis, bowel obstruction, and gastroparesis

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Starting with PlexusDx's Microdose GLP-1 Protocol ($129/mo flat) can ease this transition by introducing semaglutide at lower initial levels, reducing constipation intensity during the adjustment phase

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Some small clinical trials have also shown encouraging results. Lorenzo Leggio, MD, PhD To view or add a comment, sign in Induction is a critical moment in opioid use disorder (OUD) care