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diabetes, cardiovascular) that drive employer health costs

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This information can be valuable for your healthcare provider when determining the best treatment plan

The overall heterogeneity for MACE was low (I 2 = 15.3%, 95% uncertainty intervals, 0 and 52.3%) (Table S3)

MECHANISM CATEGORIES RESEARCH CONDITIONS SAFETY Side effects Limited human safety data Animal studies report wide therapeutic window Known interactions Methyl-donor depletion theoretical with chronic dosing (NNMT methylates nicotinamide using SAM) Contraindications Pregnancy/lactation (unstudied) REGULATORY STATUS FDA Not FDA-approved