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In addition to aesthetic treatments consider: Optimise protein intake (0.8-1.2 g/kg of body weight) to preserve muscle mass Use medical grade skincare with ingredients such as retinoids, peptides and vitamin C Stay hydrated to maintain skin elasticity While GLP-1 medications offer transformative weight loss and health benefits, they can lead to unintended facial changes

The glucagon receptor activation drives fat oxidation in the liver and improves lipid profiles

Taken together, evidence from neuroscience, human research, and clinical practice suggests meaningful overlap between obesity and addiction-related mechanisms. Lorenzo Leggio, MD, PhD, clinical director, National Institute on Drug Abuse, Bethesda, Md

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Across the GLP-1 class (semaglutide, tirzepatide), most patients regain a substantial portion of lost weight within 12 months of stopping the drug